I took Cymbalta to help combat the PN effects of chemo back in 2006-2007. I took a very large dose for a long time. Then my prescrition ran out and due to some oddball staff at my doctors office, I could not get a refill . Something like the doc is on vacation, we don't ask the partner to refill.... and so on. Had near seizure like problems, ended up in an ER after missing 4 doses. Not fun. But.....it did work!