Here's an example/explanation of what I meant above:
Quote:
Serum pregnenolone may drop to subnormal levels when patients are maintained on opioids. In these cases, patients complain that their medication is “no longer working.” Opioids may suppress pregnenolone production and require replacement as is the case with testosterone.
http://www.practicalpainmanagement.c...-2010?page=0,1
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