Originally Posted by glenntaj

--and Pregabalin (Lyrica) are both excreted almost whole through the kidneys and not appreciably metabolized through liver enzymes, the rates at which people "clear" these drugs (or, to put it another way, their "half-lives") vary considerably from person to person, and I've certainly seen people prescribed doses divided up in different ways--twice a day, three times, four times. Often some experimentation is needed to see what works best for the individual.