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Originally Posted by deafmack
I just joined this community and saw the thread on B12. I asked my doctor to test because I am on high levels of Metformin and I had read that Metformin can deplete the B12 levels in ones body. We tested and found out I was low. I started taking cyancobalamin and then changed over to Methylcobalimin. I then switched to Metanx a prescription form which has Methylcobalimin, Folic Acid and B6 which I take 2 times a day. I did not know I should take it on an empty stomach so will make that change starting tonight. My question is how long after I take the Metanx should I wait before eating?
Thanks for your reply.
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I'd wait an hour. For the sublingual types, you can chew those up and swallow with water...and I think it gets into the intestine faster. But a big solid tablet takes more time to dissolve.
The Metanx insert is very vague.
www.metanx.com/media/Metanx_PackageInsert.pdf
Does not elaborate as to the coating...on the tablet. Is it enteric coated to protect the P5P? If so it will take a long time to dissolve. There also are no directions regarding food.
Food impairs B12 absorption, because it relies on PASSIVE movement in the intestine.
This insert seems to focus on the methylfolate only.
So while Metanx appears to be a positive movement forward in treating deficiency...the product itself is promoted without regard to the needs of each ingredient.
This is a "medical food" and as such it does not have to conform to the FDA rules on drug pharmacokinetics, --meaning absorption, fate and distribution. The reason the insert focuses on methylfolate is that the FDA requires RX for folate 1 mg and over. The OTC B12 and P5P are therefore not addressed at all IMO.
Take a look at all the ingredients on that PDF... has to be the longest I've ever seen for an oral dosage form.
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Ingredients:
Dibasic Calcium Phosphate Dihydrate, Microcrystalline Cellulose 90, Microcrystalline Cellulose HD 90, Pyridoxal-5´-
Phosphate, Opadry II Purple 40L10045 (Polydextrose, Titanium Dioxide, Hypromellose 3cP, Hypromellose 6cP, Glycerol
Triacetate, Hypromellose 50cP, FD&C Blue #2, FD&C Red #40, Polyglycol 800), Microcrystalline Cellulose 50, Opadry II
Clear Y-19-7483 (Hypromellose 6cP, Maltodextrin, Hypromellose 3cP, Polyglycol 400, Hypromellose 50cP), Lmethylfolate
Calcium, Magnesium Stearate, Methylcobalamin, and Carnauba Wax.
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