Maybe it's repetitive transcranial magnetic stimulation:
Placebo-controlled study of rTMS for the treatment of Parkinson's disease
Mikhail P. Lomarev, PhD, MD 1 *, Sulada Kanchana, MD, PhD 1, William Bara-Jimenez, MD 2, Meena Iyer, PhD 3, Eric M. Wassermann, MD 3, Mark Hallett, MD 1
Abstract
The objective of this study is to assess the safety and efficacy of repetitive transcranial magnetic stimulation (rTMS) for gait and bradykinesia in patients with Parkinson's disease (PD). In a double-blind placebo-controlled study, we evaluated the effects of 25 Hz rTMS in 18 PD patients. Eight rTMS sessions were performed over a 4-week period. Four cortical targets (left and right motor and dorsolateral prefrontal cortex) were stimulated in each session, with 300 pulses each, 100% of motor threshold intensity. Left motor cortex (MC) excitability was assessed using motor evoked potentials (MEPs) from the abductor pollicis brevis. During the 4 weeks, times for executing walking and complex hand movements tests gradually decreased.
The therapeutic rTMS effect lasted for at least 1 month after treatment ended.
Right-hand bradykinesia improvement correlated with increased MEP amplitude evoked by left MC rTMS after individual sessions, but improvement overall did not correlate with MC excitability.
rTMS sessions appear to have a cumulative benefit for improving gait, as well as reducing upper limb bradykinesia in PD patients.
Although short-term benefit may be due to MC excitability enhancement, the mechanism of cumulative benefit must have another explanation. © 2005 Movement Disorder Society
http://www3.interscience.wiley.com/c...TRY=1&SRETRY=0