When I was taking it, I worked up to 100mg. 75mg at bedtime and 25mg in the morning -- or it might have been 50 mg at bedtime, 25 in the morning, and 25mg in the afternoon. I was taking this along with gabapentin.

It seemed to help, but after a year and a half or so, it seemed like it was losing effectiveness for me so I tapered off and we moved me onto Cymbalta for a while.

I ended up with profound constipation with this drug, and was taking a stool softener every day -- which, given that it says to check with your doctor after 10 days, worried me. But the docs said it was fine, just important to check with a doc in case there was an undiagnosed internal blockage, but the daily stool softener wasn't a problem since they knew what the reason for it.

I also ended up being pretty sleepy. (But since that gives me an excuse to drink more coffee, I'm okay with that. ) That was the reason for spreading out the dose, seemed to help.