P5P is the activated form for pyridoxine (B6). B6 has to be converted to P5P in the body using pyridoxal kinase enzyme.
Some people fail genetically at this step and B6 will build up in the blood from not being utilized and may cause neuro symptoms.
NOW company makes an affordable P5P product...which should be enteric coated to bypass the stomach acid, for best results.
People with conversion problems may show high homocysteine levels as a test result... because pyridoxal, folate and B12 are necessary to convert homocysteine to SAM. Having a homocysteine level run is a good indicator to show if methylation problems exist. About 10% of the population cannot metabolically handle this process and need special forms of the vitamins. The special folate is called methylfolate.
This DNA mutation affects folic acid which has to be methylated to methylfolate in the body to work. The special B12 is called methylcobalamin.
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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