Lloyd, unfortunately you will notice the offs as PD progresses. Right now you're probably well covered taking Stalevo every 3-1/2 hours, but someday, hopefully not too soon, you will begin to experience those dreaded offs.

You realize that we are taking dope and that withdrawal symptons are part of the deal. They go something like this: when your meds wear off, not only do all your PD symptons return in full bloom, but you are also provided, at no extra charge, with a virulent set of writhing dyskinesia (choreic movements), dystonia or stiffening of the most affected muscles (neck, back, feet...), can't sit or stand still, can't talk right, your face looks like it's turned to stone, you might even drool, and worst of all, you get desperate. It is then that you should quietly go to your room and rough it out until the next dose kicks in. By roughing it out I mean: do what comes natural, throw pillows or throw yourself on the floor, just pace up and down swinging your arms like a madman or cry a little. In about 20 min. your next dose will kick in and you will be home free.