--here's a thread we've sarted about alpha lipoic/R-lipoic acid on the Vitamin/Supplement board here at Neurotalk:

http://neurotalk.psychcentral.com/sh...ad.php?t=15985

I would not think you'd have trouble with B-vitamin supplements except possibly for B6; there is evidence that for certain people with enzymatic deficieincies, megadosing of B6 can lead to neuropathic symptoms:

http://www.neuro.wustl.edu/neuromusc...yridoxineintox

However, many people who suspect they might be thus affected report no problems with the P-5-P coenzymated form of B6, rather than just the usual pyridoxine that is used in most standard supplement formulations.