Mrs. D, I like you get a bit hyper taking 100 mg's daily of R-Lipoic. The only plus is having lost almost 10 lbs. since starting it. Also, feel a little jumpy. Afraid what 200 mg's would do to.I know you mentioned you had been on 200 mg's and had to go down to 100 mg's because of feeling jittery. Good Luck.