I have had carpal tunnel since I was 30 thereabouts. It became very severe
during my pregnancy when I was 34. I am also hypothyroid.
I am 60 now, and it flares sometimes. Too much fluid retention can make it
bad so I limit salt.
For years the only thing that worked was a special B6 called P5P.. this is activated form, and comes in 50mg tablets. Some people do not activate
pyridoxine to its active pyridoxal form in the liver. B2 is needed for this, enzyme to work (pyridoxal kinase) as well. I brought P5P to the net many years ago
on BrainTalk, and many people have used it with success.
I'd consider it, if I were you. Most doctors do not understand B6 chemistry at all....just ask your doctor which drug affects pyridoxal kinase. First ask him/her if he can define pyridoxal kinase! I'll tell you the answer = theophylline. But your doctor will not know this. Some doctors know that INH (isoniazid) therapy depresses B6...but that is old news and they don't know "why" as a rule.
http://www.ncbi.nlm.nih.gov/entrez/q...t_uids=2535870
Zinc is also important for B6 functions:
Quote:
Mol Cells. 2000 Aug 31;10(4):452-9. Related Articles, Links
Human pyridoxal kinase: overexpression and properties of the recombinant enzyme.
Lee HS, Moon BJ, Choi SY, Kwon OS.
Department of Biochemistry, Kyungpook National University, Taegu, Korea.
Pyridoxal kinase catalyses the phosphorylation of the vitamin B6. A human brain pyridoxal kinase cDNA was isolated, and the recombinant enzyme was overexpressed in E. coli as a fusion protein with maltose binding protein (MBP). Pure pyridoxal kinase exhibits a molecular mass of about 40 kDa when examined by SDS-PAGE and FPLC gel filtration. The recombinant enzyme is a monomer endowed with catalytic activity, indicating that the native quaternary structure of pyridoxal kinase is not a prerequisite for catalytic function. Zn2+ is the most effective divalent cation in the phosphorylation of pyridoxal, and the human enzyme has maximum catalytic activity in the narrow pH range of 5.5-6.0. The Km values for two substrates pyridoxal and ATP are 97 microM and 12 microM, respectively. In addition, the unfolding processes of the recombinant enzyme were monitored by circular dichroism. The values of the free energy change of unfolding (AGo = 1.2 kcal x mol(-1) x K(-1)) and the midpoint transition (1 M) suggested that the enzyme is more stable than ovine pyridoxal kinase against denaturation by guanidine hydrochloride. Intrinsic fluorescence spectra of the human enzyme from red-edge excitation and fluorescence quenching experiments showed that the tryptophanyl residues are not completely exposed and more accessible to neutral acrylamide than to the negatively charged iodide. The first complete set of catalytic and structural properties of human pyridoxal kinase provide valuable information for further biochemical studies on this enzyme.
PMID: 10987144 [PubMed - indexed for MEDLINE]
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I cringe every time I hear of a doctor telling patients to avoid B6... this is
just not true. The failure of pyridoxine in the body leads to deficiency and the deficiency signs are identical to the toxic ones. (and extremely high doses for long periods of time are needed for toxicity.)
This is a very up to date and complete monograph on B6:
http://lpi.oregonstate.edu/infocente...nB6/index.html
Quote:
Toxicity
Because adverse effects have only been documented from vitamin B6 supplements and never from food sources, only the supplemental form of vitamin B6 (pyridoxine) is discussed with respect to safety. Although vitamin B6 is a water-soluble vitamin and is excreted in the urine, very high doses of pyridoxine over long periods of time may result in painful neurological symptoms known as sensory neuropathy. Symptoms include pain and numbness of the extremities, and in severe cases difficulty walking. Sensory neuropathy typically develops at doses of pyridoxine in excess of 1,000 mg per day. However, there have been a few case reports of individuals who developed sensory neuropathies at doses of less than 500 mg daily over a period of months. None of the studies, in which an objective neurological examination was performed, found evidence of sensory nerve damage at intakes of pyridoxine below 200 mg/day (15). In order to prevent sensory neuropathy in virtually all individuals, the Food and Nutrition Board of the Institute of Medicine set the tolerable upper intake level (UL) for pyridoxine at 100 mg/day for adults (see table below) (4). Because placebo-controlled studies have generally failed to show therapeutic benefits of high doses of pyridoxine, there is little reason to exceed the UL of 100 mg/day.
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I found only 50mg of P5P daily gave significant improvement. I've been doing this for years now.
I use the NOW brand (which has B2 in it as well as some magnesium).
Another B that really helps is thiamine. Anyone with PN should try thiamine
as well. At least 200mg/day in divided doses.
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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