I've been DMD free for almost 3 years and feel soooooooo much better than I did taking them. I was on Avonex for 3 years, copaxone for a couple months ( the dents in my legs went away) and Rebif for a short period. Never regreted stopping all of them. Some ppl do ok on them and for that I am glad, they just weren't for me. Have had no relapses without them thank God.