I started on 200mg a day and now am at 275 a day. I've never heard of using imuran as a 2 times a day drug...may want to question your doc about this. Getting blood work done for it is different when doing so, it may require a peak and trough level, after and before.

I am weaning off imuran to see if it is helping as I also take tacrolimus and prednisone.