75mg twice a day, along with as much mestion ( both timespan and 60mg) as needed. It took about 8 weeks to get past some of the strange side effects of Imuran, another 10/14 months for results. 2 years down the road I feel better, still have all symptoms. But.... To a lesser degree and spaced further apart. I can usually self regulate how well I feel and look with mestion. Laying flat while sleeping , and summertime are still problematic.