The activity of the mu receptor (where opiates and tramadol bind)
and the serotonin transporter in cells, appears to be genetically
connected. This is very complex, and I'll give the link here.
http://www.nature.com/npp/journal/v2.../1395737a.html
This may explain why some people get itching (thought to be a serotonin effect) from some synthetic opioids. It may also explain why some refractory depressions respond to opioids.
Also interesting is buprenorphine, which is a partial mu receptor agonist. This drug has been shown effective in refractory depressions as well:
http://docs.google.com/viewer?a=v&q=...I6Fsq0QPBjFQKg
I am building a new thread for our SubForum here, and ran across this:
http://www.anesthesia-analgesia.org/.../1890.abstract
It mentions an idiosyncratic reaction that tramadol may cause in some people, BURNING! ( I have not noticed this myself).
Quote:
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CONCLUSIONS: Collectively, these findings strongly support the intriguing and novel concept that tramadol acts as an agonist of TRPV1. Considering that activation of TRPV1 on sensory neurons is followed by a local release of vasoactive neuropeptides and a marked desensitization of the afferent fibers (hence termination of pain sensation), our findings may equally explain both the desired analgesic as well as the often-seen, yet “unexpected,” local side effects (e.g., initiation of burning pain and erythema) of tramadol.
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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