IMO (of course

)
It comes down to time. It is perfectly normal to feel blue, sad, upset etc. Especially when dealing with the symptoms of MG. It is not normal to feel this all the time for an extended period of time (length of time is up for debate). When it becomes a struggle to put a smile on at all and you don't remember the last time you easily laughed, it is time to look at a medical solution to a medical condition.
I went from casually being able to pull the occasional all nighter and easily working 14 hour days to being barely able to cross my living room under my own power. Radiation therapy, pneumonia, MG all contributed to a real change in my condition and view of self. Depression is not unusual for this. It really isn't just a matter of "pulling up your socks and moving on"... it is a real condition and there is nothing wrong with taking medication for it.
Brian.