Some benefit from meds, alas I didn't. In the beginning I tried Rebif, Novantrone and ADs (to help increase endorphins.) Besides making me be sick or feel sick nothing helped. So I just take Amantadine (learned I go from dead to half dead and that is an improvement). With Vesicare in AM and Oxybutin before bed(anti-pee meds) ,I sleep all night until 5 AM and have to pee, can get out of house for awhile. If I get a neuro - pain, I sometimes take Vicodin.