I work with Deplin and just want clarify a few things. Metanx is part of the Pamlab family along with Deplin. Deplin, which is high L-methylfolate, has indication for depression symptoms. Metanx, has the unique indication specific for DPN. Metanx works by addressing the inadequate nutrition which may lead to nerve damage. Please visit the Metanx or Deplin website for more patient information. Hope this helps.