I was diagnosed with idiopathic small/large fiber sensory neuropathy a little over 3 years ago. My symptoms initially appeared to be length dependent, but over the course of 2-3 months my symptoms became body-wide. I started a supplement regime based on recommendations from these boards approximately 2 years ago and added Elavil at bedtime about a year ago. After developing autonomic neuropathy (POTS) in the spring of this year, my neurologist and I agreed that I should try IVIG. She felt that although my blood work was all negative for autoimmune disease, that my presentation was consistent with that of an autoimmune neuropathy. I am very happy to report that I have seen some definite improvement since starting IVIG. I had some fatigue, headaches, neck pain following the initial 5 daily treatments, but have had no problem tolerating subsequent treatments. I have noticed increased sensation in my hands with a decrease in the overall body-wide numbness that I have experienced. My ability to sense heat and cold in my hands/feet has also improved. I'm also no longer having migraine headaches and my POTS symptoms have significantly lessened. My constipation even appears to be improving. Overall, I am very pleased. My neuro also mentioned that we might consider a trial of Prednisone in a few months, but was concerned as to side effects. I just thought I would share my experience. I was initially very reluctant to try IVIG, but am very glad that I did. Wishing you well. Liz