Originally Posted by Ronhutton

I think I need help with this one. Two days ago I took a 50mg dose of Stavelo, together with my normal meds of rasagiline, amantadine, and trihexyphenidy at 8-00am. I switched on at 8-30am. Everything normal, but I then stayed on and on, until 3-00pm, when I switched off. That is 6.5 hours from one 5omg tablet!! I normally only get 2 to 3 hours,
What caused it, well I remembered taking a glass of fruit juice, namely grapefruit. I was aware of the restrictions of drugs and grapefruit juice but nothing generally affects me. I duplicated the experiment yesterday and again got exactly the same result.
The only negative point is safety. There are about 50 drugs which interact with grapefruit, but are any PD drugs on the list? I did a quick search, and did not find any, but we need a very careful search. Apparently grapefruit juice and certain drugs both use ther same enzyme to break down.
If it is safe, this would be a huge step forward.
Ron