Haven't been able to look into it very much as computer is gimpy, google
cortisol and microphage migration inhibitory factor. Kind of hard to understand the biochemistry and I'm not sure if I have it all straight but it stated cortisol stimulates MMIF which is a cytokine that intensifies pain and was said to eventually override the pain killing effects of cortisol. I wondered if the pain and stress of PN stimulated cortisol and the resulting MMIF stayed around longer when cortisol levels dropped, caused more pain which again stimulated cortisol which again stimulated MMIF. I don't know if I have it all straight at this point or if its is too complicated for us to understand anyhow.
Zygo