Can you tell how much B6 you were taking daily?
This link and quote is considered medically accurate today.
Quote:
Toxicity
Because adverse effects have only been documented from vitamin B6 supplements and never from food sources, safety concerning only the supplemental form of vitamin B6 (pyridoxine) is discussed. Although vitamin B6 is a water-soluble vitamin and is excreted in the urine, long-term supplementation with very high doses of pyridoxine may result in painful neurological symptoms known as sensory neuropathy. Symptoms include pain and numbness of the extremities and in severe cases, difficulty walking. Sensory neuropathy typically develops at doses of pyridoxine in excess of 1,000 mg per day. However, there have been a few case reports of individuals who developed sensory neuropathies at doses of less than 500 mg daily over a period of months. Yet, none of the studies in which an objective neurological examination was performed reported evidence of sensory nerve damage at intakes below 200 mg pyridoxine daily (24). To prevent sensory neuropathy in virtually all individuals, the Food and Nutrition Board of the Institute of Medicine set the tolerable upper intake level (UL) for pyridoxine at 100 mg/day for adults (see table below) (7). Because placebo-controlled studies have generally failed to show therapeutic benefits of high doses of pyridoxine, there is little reason to exceed the UL of 100 mg/day.
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from
http://lpi.oregonstate.edu/infocente...ins/vitaminB6/
Blood level ranges do not reflect toxicity IMO. They were compiled from "normals" who were not taking vitamins when tested.
This link explains:
http://labtestsonline.org/understand...ranges?start=0
For example, the reference range for B12 in US today, still reports, results below 400 down to 200 as normal. And current medical opinion is that this is WRONG. There can be significant neurological damage in the 200-300 range. And conversely, a result over 850-1000 is considered out of range...but for B12 there is no upper safety limit in existence. High B12 reading in people NOT taking a vitamin supplement may however indicate a rare disease that has high B12 as a sign. But for people taking B12 for improving pernicious anemia, or other neuro reason, being high is desirable.
That is just one example. Being high in something can even be factitious...potassium is one test that can be done wrong and give a false high. If the blood sample is handled in such a way that the red cells burst, then the potassium spills out into the serum and gives that sample a high reading that is not reflective of the serum without burst cells. It is believed that some nutrient testing falls into this category too.
I've looked for papers --the few papers that describe real toxicity from too much B6---which years ago were made in response to PMS treatments that used 500mg-1000mg a day of B6 to treat PMS. I could not find any blood levels on those abstracts to support the neuropathy claims. It was then that the anecdotal reports detailed B6 neuropathy toxic results.
There are just not many in fact, but doctors hold onto to potential of it just the same, as they report low B12 as normal.
The only way to know more accurately if you are really high, is to have intracellular testing. And that information is on this thread before this post.
One would expect anyone taking vitamins to show that in the blood work. Toxic ranges for DRUGS are done however as part of the FDA approval process for animals and humans. Nutrients have not been elucidated in this way for vitamins. The FDA has "recommendations" called upper safety limits for most RDA vitamins today. And the Linus Pauling link I have here gives that.
It is not really necessary for people to go over 50mg a day IMO.
Some athletes go higher because pyridoxal is needed by muscle and people with Pyroluria lose B6 rapidly in the urine, so they tend to go higher, and typically use P5P for that reason. I have not seen ONE paper demonstrating that the active form P5P has the same toxic potential as the regular pyridoxine.(which may build up if not converted to P5P in the body).
So for you it really depends on what total amount you are taking daily. Sometimes nerves "wake up" during healing and give confusing symptoms, which may be interpreted as negative, but only reflect the healing process. That can confuse issues also.
Many antibiotics for Lyme chronic treatment do deplete B6 and other vitamins. So taking "some" is a good idea. But huge amounts are not typically necessary.
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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