I started P5P over a decade ago... when my neuropathy was severe. I had terrible carpal tunnel. Over time the neuropathy got better, so I don't take the P5P every day anymore. I actually introduced P5P to our older home board...the PN and ADHD boards. In those days I used Solgar brand, as it was the only one available for a while.

There are so many actions of B6 in the body, that they must all compete for whatever is available. The muscles especially, so exercise increases needs for it.

B6 is essential for making neurotransmitters in the brain, and when my son was severely ADHD in school, I began a non-drug regimen for him. That is when I did my B6 investigations.
It remains very important today still.

If your neuropathy is from B6 deficiency it may take months to improve. It is not a swift effect. You should also investigate our Subforum at Peripheral Neuropathy, as I have a Supplements section there too. R-lipoic acid and Benfotiamine may be helpful for you, as it has been for me too. Now that I take them daily, I don't need my wrist braces nearly as often as before.

Healing up takes time. It took time to get where you are, and it will take some time to get back. But slow changes should be obvious in a couple of months. B6 is not the only player, and without a complete history of your issues, previous drug use, current drug use (antibiotics, statins, or others that can damage nerves) it is hard to recommend what to do. Magnesium works with B6, so you need to pay attention to it also.

Lyme does cause nerve damage itself independently of the depletion factor of nutrients. But I don't have experience with many Lyme patients. Sorry.

If you tell me the drugs you were on, I can look them up and see which nutrients are affected the most by the antibiotics.