I am taking 1 1/2 generic sinemet 25/100 tabs every 2 hours. The meds don't even make it dose to dose and then in the afternoon I have to decrease that or I will get dyskinesia around 2 or 3 in the afternoon that is severe.

On Tuesday morning 12/6, approx 7 in the morning, I drank about 10 ounces of Minute Maid grapefruit juice, not from concentrate and plain grapefruit, not red or pink. I then took my morning dose 1 1/2 tabs. I ate my normal breakfast of cold cereal and milk trying not to otherwise alter my routine. Normally I would expect to have to take a second dose at around 8:30. I have rarely if ever made it to the next dose without feeling some degree of off, perhaps not totally but I can feel it coming on.
I was able to maintain an "on" state until around 1 pm in the afternoon! In fact having to monitor how I was feeling so that I would not go to an "off" state did not even come to mind I was moving about so well.
It worked for me and beyond the having to drink grapefruit juice it was an enlightening experiment. Best of luck to all.