I have taken Amitriptyline for years. I took it at 50 mg. for bladder pain for 7 years before I went off it to have a baby. It worked great for my bladder pain and I definately found it helped with my depression and anxiety, even though doctors say it won't work on depression at such a low dose. After being off it for 5 years, I started it again last spring for neuropathic pain. I'm now on 40 mg. a day and it has helped with my neuropathic pain a bit, but has greatly helped my mood.