Deplin, as pure L-methylfolate, by-passes the 677CT gene defect and crosses the blood brain barrier enhancing BH4. More BH4 eventually means more of the three essential neurotransmitters. This is how Deplin aids in treating depression. If you have the gene defect, taking folic acid may actually hinder the conversion factor (see articles) and still not address the issue. Metanx is another product by Pamlab that contains L-methylfolate and also Methylcobalamin and Pyridoxal 5 Phosphate. Metanx has an indication for endothelial dysfunction and hyperhomocysteine. **