Hi my name is Kathy, just dx with MS at age 64, but had it for years, My nero is going to see me on Tuesday to talk about meds. One he wants to talk about is Tysabri,he gave me the JC test but we have not got the results back yet. The doctor wants me to come in and ask questions, he says anything I want to know about treatment and let him know my systems that are my biggest concern for me. I will do some searches on Tysabri and read your post. I have lots of brain lesions and bad legs. Now I seem to be tired all the time, but manage to go to work, Would like to know if this drug helps with these types of systems? Kathy