Have you thought about LDN? For me it's a pill or nothing. I just finished a Gilenya Study, 6 mos. I want to stay on it cause needles and infusion scares me. Gilenya is so new and expensive. I hope it works for you. I didn't have any anxiety, just pop a pill and go. All my tests came back normally but I did drop weight. I don't know if it can be attributed to MS fatigue or the Gilenya.
Good luck with whatever you choose.