I have a new theory on peripheral neuropathy.

I used to think the hyperexcitability of nerves was caused by magnesium deficiency; i.e., not enough Mg to pump the Ca out. So I kept taking Mg... but the nerves didn't quieten down, making me wonder if the Ca was still not getting expelled quickly, therefore continuing to fire ad infinitum.

I just read that you need ATP to get that Mg pump working. So even if you have plenty of Mg to drive out the Ca, it's not going to move properly without the 'batteries' (ATP) to power the pump properly?

I also read that up to 30% of the mitochondrial energy is used to run that pump. As long as the mito furnaces aren't doing their job, Mg supplements are in vain or to some extent ineffective. You have to start with fixing the furnace.

To me it seems the symptoms of too high Ca and PN can be very similar.

It seems the best rehab order is:

1) Fix mitochondrial function;

2) Increase Mg;

3) Monitor Ca (make sure it's not too high);

4) Take all the usual PN/nerve supplements.

(Low mito will limit supplement absorption?)