When a person is very low in B12 for a period of time and then
starts to supplement it, there are adjustment issues. We had a poster here Rose who has a webpage devoted to B12, and she was in bad physical shape from years of low B12. She used to post here, and often said that her recovery was marked with ups and downs and strange sensations.
This is her website:
http://sites.google.com/site/roseannster/home
this is a quote from Rose's site under treatment:
Quote:
Oral Treatment:
Goldman: Cecil Textbook of Medicine, 21st Ed., W. B. Saunders Company, Page 1056
"Oral cobalamin, 1 to 2 mg/day [1000 to 2000 mcg per day], is the treatment of choice for most patients. This [oral] dose is as effective and possibly superior to a parenteral [shots] regimen in all causes of cobalamin deficiency because 1 to 2% of an oral dose is always absorbed by diffusion. For patients who may not be compliant [may not continue treatment on their own], intramuscular or subcutaneous cyanocobalamin can be given. One approach consists of injections of 1 mg of cyanocobalamin [the cheapest and least effective form of B12] once per week for 8 weeks, then once per month for life. More frequent injections often are used in hospitalized patients or patients with marked neuropsychiatric abnormalities, but no evidence of incremental benefit has been shown. When the weekly injections are completed, the patient or a family member or friend can be taught to give the monthly injections. Parenteral and high-dose oral regimens give prompt and equivalent hematologic and neurologic responses, but post-treatment serum cobalamin levels are significantly higher and post-treatment methylmalonic acid levels are significantly lower with the oral regimen. With either the parenteral or the oral regimens, the absolute requirement of lifetime therapy must be well understood by the patient and the patient's family. Because cobalamin is inexpensive and free of side effects, it is better to give too much than too little [If there is a symptom indicating reaction, it is a good thing]."
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Doctors not only miss B12, or ignore it, they also under treat it too!
Your best therapeutic way can be controlled by you. Daily use of 5mg orally, on an empty stomach, matches the way our bodies have metabolic systems for processing B12. Injections dump 1000mcg into your system and that lasts ---drumroll-- 72 hours at best. This this the pharmacological facts of B12 injections. We did not evolve to absorb or utilize B12 in huge bolus amounts. It is a microgram nutrient. When you take it daily orally, a few micrograms will be absorbed even if you no longer have intrinsic factor. This is why you MUST use it on an empty stomach--so passive absorption is aided.
Studies have proven results with oral forms taken in at least 1000mcg DAILY doses. For people really low, or who have been low for a LONG time, I think 5mg daily (5,000 mcg) is more effective. Levels of 400 are barely normal, and in a person previously very low, should still be raised to about 1000 or more, to try to catch up all metabolic systems including the brain and spinal cord. After 3 months on 5mg oral daily, get tested again, to see what your new level is, and maintain that.
It took a period of time to get where you are now (low)...it will take time to correct.
Here is a link to Dr. Snow's expert article that explains neurological effects of low B12 and how he found some patients in the 400 range who improved with further therapy.
http://neurotalk.psychcentral.com/post698522-70.html
This is my B12 thread with studies on success with oral, and why methylcobalamin is preferred:
http://neurotalk.psychcentral.com/sh...highlight=Snow
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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