I think it has been suspected to be related to inflammation for a long time and that's why even neuros will say you should take vitamin D and get sun to lower inflammation. I think that's why Copaxone works well for so many, because it tricks the body into thinking there is inflammation in the area of the shot so the body "flares" there instead of going into attack mode on the nervous system.

That is my crude understanding of how they think Copaxone works against MS relapses.