Hello alisa and welcome to NeuroTalk

Using the Disease Modifying Drugs for MS is a personal choice, some use them and some do not. Each person will have their own reasons for not using a MS treatment.

I have never used any of the MS treatments in 26 years and I have no plans to do so.

Going 'natural' is not a treatment for this disease, it's a lifestyle choice. I'm not sure what you are looking for when asking "if anyone has had any success with supplements and natural medicine." Can you feel good? Yes, maybe. Will going natural slow progression? Unproven.

There are no gaurantees with or without medication, this disease is a crapshoot either way. Do what you feel is best for you but understand the possible risks in not treating MS with FDA approved treatments.