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Old 01-01-2012, 12:37 AM
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mrsD mrsD is offline
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mrsD mrsD is offline
Wisest Elder Ever
mrsD's Avatar
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Lightbulb

Statins for cholesterol have been shown to prevent remyelination
of nerve fibers.

Some statins like Zocor are very lipophilic and enter the brain and affect it there too.

http://www.spacedoc.com/statins_multiple_sclerosis

This study specifically targets MS damage, because at one time it was thought that statins would HELP MS but now it appears it is the opposite.

Other statins vary in how much they enter the brain. But most of them do to some extent. Zocor is just much more potent in this regard.

Avoiding statins when your goal is for brain REPAIR therefore appears to be prudent. Please discuss this with your doctor
before discontinuing any statin you may be using.

This article lists statins and their lipophilic potential (i.e. crossing the blood brain barrier and affecting nerves and muscle)

http://jama.ama-assn.org/content/295/23/2721.2.extract
Quote:
Pravastatin and rosuvastatin have low lipophilicity, atorvastatin and fluvastatin have modest lipophilicity, and simvastatin and lovastatin have high lipophilicity.1 Pravastatin, fluvastatin, and atorvastatin do not penetrate the blood-brain barrier.2
I take exception to Lipitor not crossing the BBB... Lipitor has been shown to cause memory loss in the elderly. IMO all of them are suspect at this time. When the patents expire soon on these drugs, we will see many more negative papers on them, as Big Pharma hides this information and has done so with other drug families in the past until the patents expire. Then the truth will come out as it has with other drugs this way.
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Mark in Idaho (01-01-2012)