Hi, I have MCTD and taking Plaquenil since 2006 when I was diagnosed. I am also on synthroid but I do not have Hoshimoto disease (my mom does) and I have fibromyalgia. I take magnesium daily (because I read it is good for autoimmune disease) and naproxen for inflammation. I don't know what will happen to me from this disease, I'm 61 and active. I'm glad I found this sight because I don't know anyone that has this disease and don;t know much about it. My doctor said it's wait and see what other symptoms, if any, come up. I did have frozen shoulder on both shoulders, and found when I eat white flour I have vaginal itching. I didn't associate the painful intercourse with the fibro. Something to ask my gyn.