Originally Posted by EarlG

disease peripheral neuropathy. I am a retired physician for many years and I actually retired earlier than planned because of this disorder. Although we cells in the brain. Also many of the side effects are "central" in nature (i.e., in the brain)
Now for treatment. I found that giving a bolus (daily dosage given all at once) seemed to help considerably. There may be a sound biochemical reason for this. By giving a bolus very high blood levels are attained which can then effectively block receptors on the nerve (and brain cells) for a longer period of time. By splitting the daily dosage over 2-3 times a day very high blood levels are never attained since the drug is rapidly cleared from the blood (within 2-4 hours). Now I would recommend this idea only for old veterans like me and then of course only after consultation with your physician. Those of us who have suffered from this disease know that we all search for some satisfatory relief avoiding at all costs using narcotics. Finally I would be amiss if I didn't mention the side effects -- yes dear there are always and always will be side effects to every single medication ever brought to the market. The more dramatic side effects of dizzness, somnolence etc fortunately become less pronounced with time.