Statins now linked to type II diabetes:
http://old.news.yahoo.com/s/ap/20120...thbeat_statins
This is one other study showing some statins actually lead to insulin resistance:
Quote:
Atherosclerosis. 2011 Mar;215(1):1-8. Epub 2010 Nov 2.
Differential metabolic effects of distinct statins.
Koh KK, Sakuma I, Quon MJ.
Source
Vascular Medicine and Atherosclerosis Unit, Cardiology, Gachon University, Gil Medical Center, 1198 Kuwol-dong, Namdong-gu, Incheon 405-760, Republic of Korea. kwangk@gilhospital.com
Abstract
Reciprocal relationships between endothelial dysfunction and insulin resistance suggest that therapies improving endothelial dysfunction will simultaneously improve insulin sensitivity and other metabolic parameters. However, previous studies with some statins either did not alter insulin sensitivity or promoted insulin resistance despite significant improvements in endothelial dysfunction and decreases in circulating pro-inflammatory markers. This may be due to pleiotropic or off-target effects of some statins to cause insulin resistance by diverse mechanisms unrelated to endothelial dysfunction. Indeed, there is evidence of other differential metabolic actions of distinct statins including effects on hydroxymethylglutaryl-CoA reductase inhibition, isoprotenoid synthesis, calcium release, glucose transport, insulin secretion, and/or insulin resistance. Pravastatin increases expression of adiponectin mRNA, enhances adiponectin secretion, increases plasma levels of adiponectin, and enhances insulin sensitivity in mice and humans. Clinical studies including large scale randomized controlled trials demonstrate potential differences between individual statins, with pravastatin promoting risk reduction for new onset of diabetes. Conversely, other statins including atorvastatin, rosuvastatin, and simvastatin all promote significant increase in this risk. Given the frequent concordance of metabolic diseases including diabetes, obesity, and metabolic syndrome with cardiovascular diseases associated with hyperlipidemia, it is important to understand the potential metabolic risks and benefits of therapies with distinct statins. In this review, we discuss these differential effects of statins on metabolic homeostasis and insulin sensitivity.
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
PMID:
21130454
[PubMed - indexed for MEDLINE]
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This is only one example of the emerging data on statins and insulin resistance. More are out there like the Yahoo article, and I think once the patents on Lipitor and Crestor expire, we will see many more negative studies.
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