To the contrary, I lost weight. This was largely due to changes in diet and exercise. As I understand, Prednisone in low dosage does not normally cause weight gain or the other negative side effects attributed to this drug. It can be dangerous as long term use can supplant adrenalin production and teach the body to rely on the drug for normal adrenal gland functioning. This is generally considered by physicians in prescribing the drug. So we are being vigilant and weighing the risks in this process.