Thanks, for your input. maybe I expect to much from sinemet. I did not know that it would be less efective with time .I was dgn'ed in 2001 and have been on sinemet for about seven to 8 years. I have used some add on's but always went back to sinemet only. 2 tabs every 3hrs 25/100. I have shortened the time to 2 1/2 but its still seem marginal. I'll see my neuro on Monday. I let you all what she says. Thanks again
Geraldo