Since Christmas I have been following the approach that the swings in L-dopa supply to our brains are themselves a problem and possibly even destructive as they stress the system with a constant roller coaster effect. Since our bodies seem to be trying to maintain a steady state it makes sense IMHO to try for the same.
As a result, I have gone from taking a single sinemet 10/100 plus a single sinemet CR 50/200 every two hours (total Ldopa 2400 mg daily but no other meds) to taking two sinemet CR 50/200 every three hours (total Ldopa 2400 mg daily with no other meds).
I feel that there have been some definite improvements. I have almost no "off" time and the freezing that comes with it, for example. I wake up in a little better condition than before and have less difficulty wobbling from bed to the bridge of the SS Enterprise ( ). Greater stability throughout the day. And, if I resist the temptation to skip the 9:00 PM dose, I stand a good chance of making it to bed without frightening my wife.

Has anyone compared these two approaches and can it be sustained?