Quote:
Originally Posted by joojee22
Although the gabapentin maybe making you feel funny, this is also true for the percocetts:
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Quote:
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Buprenorphine itself binds more strongly to receptors in the brain than do other opioids, making it more difficult for opioids (or opiates) to react when buprenorphine is in the system. The blockade effect also has the result of blocking endogenous endorphins from binding to receptors, which can lead to psychological alterations in mood and mental capacity. This can cause cognitive and memory deficiencies via blockade of the reward system, which is pertinent to memory formation and normal mental function.
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What I get that says, which appears to have been considerably altered from the original:
http://en.wikipedia.org/wiki/Buprenorphine
is that the
butrans would be the cause of cognitive and memory deficiencies by blocking the
endogenous endorphins from binding to the receptors - not the percocet.
Oxycodone has some deliterious effects on some few patients, but generally with opioid-naive patients. More often it may have euphoric/calming effects, which wear off in time, (would be blocked by the butrans) and would not be likely with a patient who has taken percocet for a very long time.
The two 800 lb. gorillas in the room appear to be the butrans and/or gabapentin, and since the problematical effects seem to be abating, this (hopefully) won't be an issue for very much longer anyway.
Doc