Hello Namaste,
I have have had PD for 11 years also. I had doing ok on two tabs of Sinemet 25/100 (manufactured by BMS). My pharma changed me to pills mfg. by Merck and theyare not very effective. My neuro has added Mirapex. I have not been on the mirapex and Sinemet long egough to see if it helps me. I have also been expermenting with sinemet cr(mfg.BMS) at night and feel much better at night when I have to get up. Who is the manufacture of your Sinemet IR and CR. The generic drug makers have different formulas and some work better than others. Tanks for sharing your info.
Geraldo.