http://www.sciencedirect.com/science...c57ec46e02d5e2
Genomics.
2003 Jul;82(1):1-9.
Cntnap2 is disrupted in a family with gilles de la tourette syndrome and obsessive compulsive disorder
Verkerk AJ, Mathews CA, Joosse M, Eussen BH, Heutink P, Oostra BA; Tourette Syndrome Association International Consortium for Genetics.
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http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum
Eur J Hum Genet.
2007 Mar 28
Disruption of the CNTNAP2 gene in a t(7;15) translocation family
without symptoms of Gilles de la Tourette syndrome.
Belloso JM, Bache I, Guitart M, Caballin MR, Halgren C, Kirchhoff M, Ropers HH, Tommerup N, Tumer Z.
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In this study, we describe a familial balanced reciprocal translocation t(7;15)(q35;q26.1) in phenotypically normal individuals. The 7q35 breakpoint disrupts the CNTNAP2 gene, indicating that truncation of this gene does not necessarily lead to the symptoms of the complex Gilles de la Tourette syndrome.European Journal of Human Genetics advance online publication, 28 March 2007; doi:10.1038/sj.ejhg.5201824.
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