Thanks MrsD. I agreee that there isn't a lot of research regarding the use of adenoslycobalmin. It is a topic that doesn't get much attention. I think it should.

What really interests me is that this form of active B12 functions in the mitochondria by being at the base of the Kreb's cycle producing ATP. With all of the current interest in mitchondria damage and how it relates to PN, it seems like Ad12 could be a crtical cofactor in the reapir of nerve damage.

It appears that most people convert a portion of Mb12 to adenosylb12 within their body. I wonder if the conversion process is enough to recover from a potential deficiency of this active form of B12.

I have been taking this form of B12 along with Mb12 as an insurance policy to what I believe is improving my PN. Unfortunately, we just don't have enough solid information out there to know if this active form should be supplemented or not. Fortunately like MB12 there is very little risk of taking too much of this on a daily basis.