Again, that would depend on amount. Mannitol is one of those things not approved by the FDA for use in cats & dogs, but commonly used in veterinary medicine, particularly to rid the eyes & brain of excess fluid following trauma. So I would expect large amounts to be dangerous.

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The sublingual B12 I currently have contains mannitol; another supplement contains mannitol and sorbitol.

We tend to put everything on hold (and the dog in his crate) any time anything in pill form is dropped on the floor anyway. Common sense kicks in.

Doc