Abby, I wanted to let you know that I am seropositive for binding and mestinon does NOT help me. I went on it, then went off it to clear up some GI issues, and went back on it. It never helped. I am now on neostigmine, which does help somewhat. So far IVIG helped my breathing problems more than anything, but neostigmine does seem to help take the edge off of them. We need to get more aggressive but I am trying to get in to get my thymic tissue removed before the end of Feb (not sure it'll happen) due to an upcoming change on my insurance, so I haven't pushed my neuro much yet.