I can't take most NSAIDs because they make me bleed if I take more than one dose. I can tolerate acetaminophen quite well. At times when I do have to take acetaminopen for prolonged periods (but still within the new guidelines), I also take NAC daily as a prophylactic against liver damage. I get my liver function tested annually, and not so much as a blip in the past ten years. In fact, they're one of those tests for which more than one doctor has told me they know patients who'd pay money for my test results.

http://yarchive.net/med/tylenol.html
(discussion about NAC begins about halfway down)

Doc