I just added this study to my Benfotiamine link:
Quote:
Int J Clin Pharmacol Ther. 1996 Feb;34(2):47-50.
Pharmacokinetics of thiamine derivatives especially of benfotiamine.
Loew D.
Source
Wuppertal, Germany.
Abstract
Pharmacokinetic data of orally administered lipid-soluble thiamine analogues like benfotiamine are reviewed and assessed. It is quite clear that benfotiamine is absorbed much more better than water-soluble thiamine salts: maximum plasma levels of thiamine are about 5 times higher after benfotiamine, the bioavailability is at maximum about 3.6 times as high as that of thiamine hydrochloride and better than other lipophilic thiamine derivates. The physiological activity (alphaETK) increased only after benfotiamine was given. Due to its excellent pharmacokinetic profile benfotiamine should be preferred in treatment of relevant indications.
PMID:
8929745
[PubMed - indexed for MEDLINE]
Publication Types, MeSH Terms, Substances
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This fat soluble form of Thiamine is far better absorbed than regular Thiamine. The old dose of thiamine for PN was 300mg a day or less. This is before gabapentin hit the shelves!
Because it is so much more absorbed, and because it stays around LONGER...not excreted so quickly... I have qualms about such high doses. I searched PubMed recently and there are no papers to speak of for this nutrient on dosing. I found ONE paper for cardiac damage indicating 400mg a day in a small subset of patients. I found only 2 pgs on PubMed, and those were mostly in animals, and from other countries.
So I will remind people here, that the high 600mg or more dose a day... comes from sites that sell this. For that reason, I personally cannot endorse it at those levels or beyond.
But since this is OTC...you can do what you choose, based on what you learn about it. If you decide to do this very high dose, just be very vigilant. It may be that only weeks are needed for this way. There is no evidence that really LONG term use, is safe yet, or that effective for most people.
I, myself, take 150mg a day. This keeps me from severe burning.
I also drink moderately 2 or 3 times a week, depending.
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Weezie looking at petunias 8.25.2017
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