Testing for parasites is not a bad idea and is probably overlooked in most cases.

My current investigative path is on the subject of MTHFR gene polymorphism. It appears that a very significant portion of the human population (maybe 20-35%) have a genetic mutation that inhibits the production of converting synthetic folic acid into the active form of L 5 methyl-tetrahydrofolate. I have also read that these mutations can cause synthetic folic acid to compete with the active form thus causing a deficiency in that individual despite them supplementing with both types on a daily basis. That is the part that got my attention. My B-complex, country life Ad12, and multi-vitamins all had folic acid which I took everyday. I also took Metafolin which is the active form. Could there be a problem where the synthetic form neutralizes the active type through competition in the MTHR process? I have read of this ocuring in some patients where it was resolved by them taking the active form only. This phenomena appears to be getting more attention by the medical community. It might be more prevalent than we think.

My history of using acid blockers for many years combined with too much drinking likely effected my nutritional absorption of B12, folate, etc.

Folate deficiency can mimic the same symptons as B12 deficiency as stated in the article below:

http://emedicine.medscape.com/article/1171558-clinical


I removed all synthetic forms of folate ( except those found in some foods like bread) from my diet and now use the active form. This started about 3-4 months ago.

My memory the last couple months has made a noticeable improvement. My overall PN symptoms also have diminished somewhat. Time will tell if I'm on the right path.

The simple fact that MTHFR gene polymorphisms are so common should be something other people consider and look at. Also, consider using just the active form of folate in lieu of the synthetic type.