I was accepted into the trial almost two weeks ago. Haven't seen any changes yet. My doctor advised not to expect any changes for at least 30 days. I take my dose each morning with breakfast at 7:00am. The first dose had me thinking I was taking liquid ExLax :-) but I quickly learned to eat 1/2 my breakfast take the dose then finish the remainder of breakfast. Blueberry yogurt with extra blueberries & muffin or toast seems to eliminate the GI issues. Limiting liquids at breakfast also helped. So my morning coffee is now at 9:00am after daily work out at the Y.
DonLee I'll send you a PM