They need to look at us more. For the clinical trials they want people with specific circumstances that they predefine. It weeds a lot of us out, the ones who are 'atypical' or the ones with pre-existing other conditions that might complicate the statistics. And they mostly have to be de novo, not on medication......... but I'm guessing that it is the people who are anomalous who will carry some of the clues. Wasn't it people with postencephalitic parkinsonism being treated with ldopa that paved the way for our treatments........